mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells

Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive. GBA1 mutations are also the most frequent genetic risk factors for Parkinson's dise...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Brown, Robert A., Voit, Antanina, Srikanth, Manasa P., Thayer, Julia A., Kingsbury, Tami J., Jacobson, Marlene A., Lipinski, Marta M., Feldman, Ricardo A., Awad, Ola
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826018/
https://ncbi.nlm.nih.gov/pubmed/31519738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038596
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker