Altered Differentiation Potential of Gaucher’s Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation

Gaucher’s disease (GD) is an autosomal recessive disorder caused by mutations in the GBA1 gene, which encodes acid β-glucocerebrosidase (GCase). Severe GBA1 mutations cause neuropathology that manifests soon after birth, suggesting that GCase deficiency interferes with neuronal development. We found...

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Publicado no:Stem Cell Reports
Main Authors: Awad, Ola, Panicker, Leelamma M., Deranieh, Rania M., Srikanth, Manasa P., Brown, Robert A., Voit, Antanina, Peesay, Tejasvi, Park, Tea Soon, Zambidis, Elias T., Feldman, Ricardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785733/
https://ncbi.nlm.nih.gov/pubmed/29198828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.10.029
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