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Anti-tumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade
T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates anti-tumor efficacy. In contrast to canonical TCR-induced activation, homeostatic activation yields a distinct phenotype and memory state whose regulatory mechanisms are poorly understood. Here, we show in...
Shranjeno v:
| izdano v: | Cancer Discov |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825548/ https://ncbi.nlm.nih.gov/pubmed/31375522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0391 |
| Oznake: |
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