Anti-tumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade

T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates anti-tumor efficacy. In contrast to canonical TCR-induced activation, homeostatic activation yields a distinct phenotype and memory state whose regulatory mechanisms are poorly understood. Here, we show in...

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Publicado en:Cancer Discov
Autores principales: Marshall, Netonia, Hutchinson, Keino, Marron, Thomas U, Aleynick, Mark, Hammerich, Linda, Upadhyay, Ranjan, Svensson-Arvelund, Judit, Brown, Brian D, Merad, Miriam, Brody, Joshua D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825548/
https://ncbi.nlm.nih.gov/pubmed/31375522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0391
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