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SCN5A Variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells
BACKGROUND: The cardiac sodium channel (SCN5A) mutation, R222Q, neutralizes a positive charge in the domain I voltage sensor. Mutation carriers display very frequent ectopy and dilated cardiomyopathy (DCM). OBJECTIVES: To describe the effect of SCN5A R222Q on murine myocyte and Purkinje fiber electr...
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| Publicado no: | Heart Rhythm |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825529/ https://ncbi.nlm.nih.gov/pubmed/31125670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2019.05.017 |
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