SCN5A Variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells

BACKGROUND: The cardiac sodium channel (SCN5A) mutation, R222Q, neutralizes a positive charge in the domain I voltage sensor. Mutation carriers display very frequent ectopy and dilated cardiomyopathy (DCM). OBJECTIVES: To describe the effect of SCN5A R222Q on murine myocyte and Purkinje fiber electr...

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Detaylı Bibliyografya
Yayımlandı:Heart Rhythm
Asıl Yazarlar: Daniel, Laura L., Yang, Tao, Kroncke, Brett, Hall, Lynn, Stroud, Dina, Roden, Dan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825529/
https://ncbi.nlm.nih.gov/pubmed/31125670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2019.05.017
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