The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo

Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET kinase and the RAS-MAPK pathway have previously been...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Flynn, Sean M., Lesperance, Jacqueline, Macias, Andrew, Phanhthilath, Nikki, Paul, Megan Rose, Kim, Jong Wook, Tamayo, Pablo, Zage, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824878/
https://ncbi.nlm.nih.gov/pubmed/31695841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27259
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