Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One such isoform, Drp1(ABCD), contains all four alternative exons and is spec...

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Vydáno v:eLife
Hlavní autoři: Itoh, Kie, Murata, Daisuke, Kato, Takashi, Yamada, Tatsuya, Araki, Yoichi, Saito, Atsushi, Adachi, Yoshihiro, Igarashi, Atsushi, Li, Shuo, Pletnikov, Mikhail, Huganir, Richard L, Watanabe, Shigeki, Kamiya, Atsushi, Iijima, Miho, Sesaki, Hiromi
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824841/
https://ncbi.nlm.nih.gov/pubmed/31603426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44739
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