Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

The serum- and glucocorticoid-regulated kinase (SGK) isoforms contribute resistance to cancer therapies targeting the PI3K pathway. SGKs are homologous to Akt and these kinases display overlapping specificity and phosphorylate several substrates at the same residues, such as TSC2 to promote tumor gr...

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Vydáno v:Biochem J
Hlavní autoři: Malik, Nazma, Nirujogi, Raja S., Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R., Gourlay, Robert, Trost, Matthias, Alessi, Dario R., Karapetsas, Athanasios
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824681/
https://ncbi.nlm.nih.gov/pubmed/31665227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190608
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