Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX...

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Detalhes bibliográficos
Main Authors: Bago, Ruzica, Malik, Nazma, Munson, Michael J., Prescott, Alan R., Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G., Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2014
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209782/
https://ncbi.nlm.nih.gov/pubmed/25177796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140889
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