Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of co...

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發表在:JCI Insight
Main Authors: Castro, Joel, Harrington, Andrea M., Lieu, TinaMarie, Garcia-Caraballo, Sonia, Maddern, Jessica, Schober, Gudrun, O’Donnell, Tracey, Grundy, Luke, Lumsden, Amanda L., Miller, Paul, Ghetti, Andre, Steinhoff, Martin S., Poole, Daniel P., Dong, Xinzhong, Chang, Lin, Bunnett, Nigel W., Brierley, Stuart M.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824308/
https://ncbi.nlm.nih.gov/pubmed/31536477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131712
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