Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of co...

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Pubblicato in:JCI Insight
Autori principali: Castro, Joel, Harrington, Andrea M., Lieu, TinaMarie, Garcia-Caraballo, Sonia, Maddern, Jessica, Schober, Gudrun, O’Donnell, Tracey, Grundy, Luke, Lumsden, Amanda L., Miller, Paul, Ghetti, Andre, Steinhoff, Martin S., Poole, Daniel P., Dong, Xinzhong, Chang, Lin, Bunnett, Nigel W., Brierley, Stuart M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824308/
https://ncbi.nlm.nih.gov/pubmed/31536477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131712
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