Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within visceral pathways. We show that subsets of co...

詳細記述

保存先:
書誌詳細
出版年:JCI Insight
主要な著者: Castro, Joel, Harrington, Andrea M., Lieu, TinaMarie, Garcia-Caraballo, Sonia, Maddern, Jessica, Schober, Gudrun, O’Donnell, Tracey, Grundy, Luke, Lumsden, Amanda L., Miller, Paul, Ghetti, Andre, Steinhoff, Martin S., Poole, Daniel P., Dong, Xinzhong, Chang, Lin, Bunnett, Nigel W., Brierley, Stuart M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2019
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824308/
https://ncbi.nlm.nih.gov/pubmed/31536477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131712
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