Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate non-enzymatic peptide bond cleavages

We report ion mobility spectrometry and mass spectrometry studies of the non-enzymatic step-by-step degradation of substance P (subP), an eleven-residue neuropeptide, with the sequence Arg(1)-Pro(2)-Lys(3)-Pro(4)-Gln(5)-Gln(6)-Phe(7)-Phe(8)-Gly(9)-Leu(10)-Met(11)-NH(2), in ethanol. At elevated solut...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Am Soc Mass Spectrom
Hoofdauteurs: Conant, Christopher R., Fuller, Daniel R., El-Baba, Tarick J., Zhang, Zhichao, Russell, David H., Clemmer, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824264/
https://ncbi.nlm.nih.gov/pubmed/30980380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02159-w
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items