Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate non-enzymatic peptide bond cleavages

We report ion mobility spectrometry and mass spectrometry studies of the non-enzymatic step-by-step degradation of substance P (subP), an eleven-residue neuropeptide, with the sequence Arg(1)-Pro(2)-Lys(3)-Pro(4)-Gln(5)-Gln(6)-Phe(7)-Phe(8)-Gly(9)-Leu(10)-Met(11)-NH(2), in ethanol. At elevated solut...

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Publicado en:J Am Soc Mass Spectrom
Autores principales: Conant, Christopher R., Fuller, Daniel R., El-Baba, Tarick J., Zhang, Zhichao, Russell, David H., Clemmer, David E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824264/
https://ncbi.nlm.nih.gov/pubmed/30980380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02159-w
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