Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate

Amlodipine, a L-type calcium channel blocker, has been reported to have a neuroprotective effect in brain ischemia. Mitochondrial calcium overload leads to apoptosis of cells in neurologic diseases. We evaluated the neuroprotective effects of amlodipine camsylate (AC) on neural stem cells (NSCs) inj...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Park, Hyun-Hee, Han, Myung-Hoon, Choi, Hojin, Lee, Young Joo, Kim, Jae Min, Cheong, Jin Hwan, Ryu, Je Il, Lee, Kyu-Yong, Koh, Seong-Ho
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823474/
https://ncbi.nlm.nih.gov/pubmed/31673096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52083-y
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