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Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate

Amlodipine, a L-type calcium channel blocker, has been reported to have a neuroprotective effect in brain ischemia. Mitochondrial calcium overload leads to apoptosis of cells in neurologic diseases. We evaluated the neuroprotective effects of amlodipine camsylate (AC) on neural stem cells (NSCs) inj...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, Hyun-Hee, Han, Myung-Hoon, Choi, Hojin, Lee, Young Joo, Kim, Jae Min, Cheong, Jin Hwan, Ryu, Je Il, Lee, Kyu-Yong, Koh, Seong-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823474/
https://ncbi.nlm.nih.gov/pubmed/31673096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52083-y
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