Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate

Amlodipine, a L-type calcium channel blocker, has been reported to have a neuroprotective effect in brain ischemia. Mitochondrial calcium overload leads to apoptosis of cells in neurologic diseases. We evaluated the neuroprotective effects of amlodipine camsylate (AC) on neural stem cells (NSCs) inj...

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Vydáno v:Sci Rep
Hlavní autoři: Park, Hyun-Hee, Han, Myung-Hoon, Choi, Hojin, Lee, Young Joo, Kim, Jae Min, Cheong, Jin Hwan, Ryu, Je Il, Lee, Kyu-Yong, Koh, Seong-Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823474/
https://ncbi.nlm.nih.gov/pubmed/31673096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52083-y
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