S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates

We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilises Rad51-DNA filaments and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find that Srs2 activity is required for normal meiotic progression...

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Détails bibliographiques
Publié dans:Chromosoma
Auteurs principaux: Hunt, Laura J., Ahmed, Emad A., Kaur, Hardeep, Ahuja, Jasvinder S., Hulme, Lydia, Chou, Ta-Chung, Lichten, Michael, Goldman, Alastair S. H.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2019
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823294/
https://ncbi.nlm.nih.gov/pubmed/31069484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00412-019-00705-9
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