MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic

Mitochondrial toxicity is a primary source of pre-clinical drug attrition, black box warning and post-market drug withdrawal. Methods that detect mitochondrial toxicity as early as possible during the drug development process are required. Here we introduce a new method for detecting mitochondrial t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Contreras-Baeza, Yasna, Ceballo, Sebastián, Arce-Molina, Robinson, Sandoval, Pamela Y., Alegría, Karin, Barros, Luis Felipe, San Martín, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822764/
https://ncbi.nlm.nih.gov/pubmed/31671132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224527
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