Proteoform-Resolved FcɤRIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties

Fcɤ receptors (FcɤR) mediate key functions in immunological responses. For instance, FcɤRIIIa is involved in antibody-dependent cell-mediated cytotoxicity (ADCC). FcɤRIIIa interacts with the fragment crystallizable (Fc) of immunoglobulin G (IgG). This interaction is known to be highly dependent on I...

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Udgivet i:Front Chem
Main Authors: Lippold, Steffen, Nicolardi, Simone, Wuhrer, Manfred, Falck, David
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822288/
https://ncbi.nlm.nih.gov/pubmed/31709228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00698
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