Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop

Hypoxia is associated with poor prognosis and therapeutic resistance in cancer patients. Accumulating evidence has shown that microRNA (miRNA) plays an important role in the acquired drug resistance in colorectal carcinoma (CRC). However, the role of miRNA in hypoxia-induced CRC drug resistance rema...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Xu, Ke, Zhan, Yueping, Yuan, Zeting, Qiu, Yanyan, Wang, Haijing, Fan, Guohua, Wang, Jie, Li, Wei, Cao, Yijun, Shen, Xian, Zhang, Jun, Liang, Xin, Yin, Peihao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822233/
https://ncbi.nlm.nih.gov/pubmed/31208913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.05.017
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