Transgenic mouse models expressing human and macaque prion protein exhibit similar prion susceptibility on a strain-dependent manner

Cynomolgus macaque has been used for the evaluation of the zoonotic potential of prion diseases, especially for classical-Bovine Spongiform Encephalopathy (classical-BSE) infectious agent. PrP amino acid sequence is considered to play a key role in the susceptibility to prion strains and only one am...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Espinosa, Juan Carlos, Comoy, Emmanuel E., Marin-Moreno, Alba, Aguilar-Calvo, Patricia, Birling, Marie-Christine, Pitarch, José Luis, Deslys, Jean-Philippe, Torres, Juan María
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821920/
https://ncbi.nlm.nih.gov/pubmed/31666632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52155-z
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