Загрузка...
Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key protein associated with Parkinson’s disease. The underlying molecular mechanism behind α-synuclein aggregation inhib...
Сохранить в:
| Опубликовано в: : | Commun Biol |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6821844/ https://ncbi.nlm.nih.gov/pubmed/31701024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0644-7 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|