S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson’s disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate...

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Pubblicato in:Sci Rep
Autori principali: Kumar, Roshan, Jangir, Deepak K., Verma, Garima, Shekhar, Shashi, Hanpude, Pranita, Kumar, Sanjay, Kumari, Raniki, Singh, Nirpendra, Sarovar Bhavesh, Neel, Ranjan Jana, Nihar, Kanti Maiti, Tushar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353675/
https://ncbi.nlm.nih.gov/pubmed/28300150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44558
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