S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson’s disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kumar, Roshan, Jangir, Deepak K., Verma, Garima, Shekhar, Shashi, Hanpude, Pranita, Kumar, Sanjay, Kumari, Raniki, Singh, Nirpendra, Sarovar Bhavesh, Neel, Ranjan Jana, Nihar, Kanti Maiti, Tushar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353675/
https://ncbi.nlm.nih.gov/pubmed/28300150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44558
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