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Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK
HMCES and yedK were recently identified as sensors of abasic sites in ssDNA. In this study, we present multiple crystal structures captured in the apo-, nonspecific-substrate-binding, specific-substrate-binding, and product-binding states of yedK. In combination with biochemical data, we unveil the...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6821365/ https://ncbi.nlm.nih.gov/pubmed/31504793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz744 |
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