Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A(2A) receptor

Accumulating data support the role of tau pathology in cognitive decline in ageing and Alzheimer’s disease, but underlying mechanisms remain ill-defined. Interestingly, ageing and Alzheimer’s disease have been associated with an abnormal upregulation of adenosine A(2A) receptor (A(2A)R), a fine tune...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Carvalho, Kevin, Faivre, Emilie, Pietrowski, Marie J, Marques, Xavier, Gomez-Murcia, Victoria, Deleau, Aude, Huin, Vincent, Hansen, Jan N, Kozlov, Stanislav, Danis, Clément, Temido-Ferreira, Mariana, Coelho, Joana E, Mériaux, Céline, Eddarkaoui, Sabiha, Gras, Stéphanie Le, Dumoulin, Mélanie, Cellai, Lucrezia, Landrieu, Isabelle, Chern, Yijuang, Hamdane, Malika, Buée, Luc, Boutillier, Anne-Laurence, Levi, Sabine, Halle, Annett, Lopes, Luisa V, Blum, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821333/
https://ncbi.nlm.nih.gov/pubmed/31599329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz288
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