Beneficial Effect of a Selective Adenosine A(2A) Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Consumption of caffeine, a non-selective adenosine A(2A) receptor (A(2A)R) antagonist, reduces the risk of developing Alzheimer’s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease. While short-term treatment with A(2A)R antagonists have been shown to a...

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Foilsithe in:Front Mol Neurosci
Main Authors: Faivre, Emilie, Coelho, Joana E., Zornbach, Katja, Malik, Enas, Baqi, Younis, Schneider, Marion, Cellai, Lucrezia, Carvalho, Kevin, Sebda, Shéhérazade, Figeac, Martin, Eddarkaoui, Sabiha, Caillierez, Raphaëlle, Chern, Yijuang, Heneka, Michael, Sergeant, Nicolas, Müller, Christa E., Halle, Annett, Buée, Luc, Lopes, Luisa V., Blum, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052540/
https://ncbi.nlm.nih.gov/pubmed/30050407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00235
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