The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice

Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality. Transforming growth factor beta 1 (TGFβ1) is elevated during liver injury and influences hepatocyte senescence during APAP-induced hepatotoxicity. This st...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: McMillin, Matthew, Grant, Stephanie, Frampton, Gabriel, Petrescu, Anca D, Williams, Elaina, Jefferson, Brandi, DeMorrow, Sharon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Organ Specific Toxicology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821297/
https://ncbi.nlm.nih.gov/pubmed/31132129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz122
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