LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-a...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Izumikawa, Keiichi, Ishikawa, Hideaki, Yoshikawa, Harunori, Fujiyama, Sally, Watanabe, Akira, Aburatani, Hiroyuki, Tachikawa, Hiroyuki, Hayano, Toshiya, Miura, Yutaka, Isobe, Toshiaki, Simpson, Richard J, Li, Li, Min, Jinrong, Takahashi, Nobuhiro
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821171/
https://ncbi.nlm.nih.gov/pubmed/31504794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz747
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