LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Izumikawa, Keiichi, Ishikawa, Hideaki, Yoshikawa, Harunori, Fujiyama, Sally, Watanabe, Akira, Aburatani, Hiroyuki, Tachikawa, Hiroyuki, Hayano, Toshiya, Miura, Yutaka, Isobe, Toshiaki, Simpson, Richard J, Li, Li, Min, Jinrong, Takahashi, Nobuhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
RNA and RNA-protein complexes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821171/
https://ncbi.nlm.nih.gov/pubmed/31504794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz747
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi