LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Izumikawa, Keiichi, Ishikawa, Hideaki, Yoshikawa, Harunori, Fujiyama, Sally, Watanabe, Akira, Aburatani, Hiroyuki, Tachikawa, Hiroyuki, Hayano, Toshiya, Miura, Yutaka, Isobe, Toshiaki, Simpson, Richard J, Li, Li, Min, Jinrong, Takahashi, Nobuhiro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
RNA and RNA-protein complexes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821171/
https://ncbi.nlm.nih.gov/pubmed/31504794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz747
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