LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-a...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Izumikawa, Keiichi, Ishikawa, Hideaki, Yoshikawa, Harunori, Fujiyama, Sally, Watanabe, Akira, Aburatani, Hiroyuki, Tachikawa, Hiroyuki, Hayano, Toshiya, Miura, Yutaka, Isobe, Toshiaki, Simpson, Richard J, Li, Li, Min, Jinrong, Takahashi, Nobuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821171/
https://ncbi.nlm.nih.gov/pubmed/31504794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz747
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