A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice

Pathological tau correlates well with cognitive impairments in Alzheimer’s disease (AD) patients and therefore represents a promising target for immunotherapy. Targeting an appropriate B cell epitope in pathological tau could in theory produce an effective reduction of pathology without disrupting t...

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Pubblicato in:Sci Rep
Autori principali: Hovakimyan, Armine, Antonyan, Tatevik, Shabestari, Sepideh Kiani, Svystun, Olga, Chailyan, Gor, Coburn, Morgan A., Carlen-Jones, William, Petrushina, Irina, Chadarevian, Jean Paul, Zagorski, Karen, Petrovsky, Nikolai, Cribbs, David H., Agadjanyan, Michael G., Ghochikyan, Anahit, Davtyan, Hayk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820729/
https://ncbi.nlm.nih.gov/pubmed/31664089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51809-2
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