A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice

Pathological tau correlates well with cognitive impairments in Alzheimer’s disease (AD) patients and therefore represents a promising target for immunotherapy. Targeting an appropriate B cell epitope in pathological tau could in theory produce an effective reduction of pathology without disrupting t...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Hovakimyan, Armine, Antonyan, Tatevik, Shabestari, Sepideh Kiani, Svystun, Olga, Chailyan, Gor, Coburn, Morgan A., Carlen-Jones, William, Petrushina, Irina, Chadarevian, Jean Paul, Zagorski, Karen, Petrovsky, Nikolai, Cribbs, David H., Agadjanyan, Michael G., Ghochikyan, Anahit, Davtyan, Hayk
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820729/
https://ncbi.nlm.nih.gov/pubmed/31664089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51809-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items