Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110

BACKGROUND: Population modeling and simulations can be used to facilitate the conduct of Phase I studies to develop safe and effective dosing regimens in neonates. SETTING: P1110 is an international, multicenter trial to determine safe and effective raltegravir doses in neonates at risk for HIV infe...

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Veröffentlicht in:J Acquir Immune Defic Syndr
Hauptverfasser: Clarke, Diana F, Mirochnick, Mark, Acosta, Edward P, Capparelli, Edmund, Chain, Anne, Teppler, Hedy, Smith, Betsy, Lommerse, Jos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820708/
https://ncbi.nlm.nih.gov/pubmed/31658182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002149
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