Increased yields and biological potency of knob-into-hole-based soluble MHC class II molecules

Assembly of soluble peptide-major histocompatibility complex class II (pMHCII) monomers into multimeric structures enables the detection of antigen-specific CD4(+) T cells in biological samples and, in some configurations, their reprogramming in vivo. Unfortunately, current MHCII-αβ chain heterodime...

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發表在:Nat Commun
Main Authors: Serra, Pau, Garabatos, Nahir, Singha, Santiswarup, Fandos, César, Garnica, Josep, Solé, Patricia, Parras, Daniel, Yamanouchi, Jun, Blanco, Jesús, Tort, Meritxell, Ortega, Mireia, Yang, Yang, Ellestad, Kristofor K., Santamaria, Pere
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820532/
https://ncbi.nlm.nih.gov/pubmed/31664029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12902-2
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