A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1

The global health burden for hepatitis C virus (HCV) remains high, despite available effective treatments. To eliminate HCV, a prophylactic vaccine is needed. One major challenge in the development of a vaccine is the genetic diversity of the virus, with 7 major genotypes and many subtypes. A global...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Johnson, Janelle, Freedman, Holly, Logan, Michael, Wong, Jason Alexander Ji-Xhin, Hockman, Darren, Chen, Chao, He, Jianqi, Beard, Michael R., Eyre, Nicholas S., Baumert, Thomas F., Tyrrell, D. Lorne, Law, John L. M., Houghton, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819942/
https://ncbi.nlm.nih.gov/pubmed/31462563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00810-19
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