Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Induces STAT2 Degradation To Inhibit Interferon Signaling

Interferons (IFNs) play a crucial role in host antiviral response by activating the JAK/STAT (Janus kinase/signal transducer and activator of transcription) signaling pathway to induce the expression of myriad genes. STAT2 is a key player in the IFN-activated JAK/STAT signaling. Porcine reproductive...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Yang, Liping, He, Jia, Wang, Rong, Zhang, Xinheng, Lin, Shaoli, Ma, Zexu, Zhang, Yanjin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819925/
https://ncbi.nlm.nih.gov/pubmed/31462568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01352-19
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