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Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain

Porcine reproductive and respiratory syndrome virus (PRRSV) strain A2MC2 induces type I interferons in cultured cells. The objective of this study was to attenuate this strain by serial passaging in MARC-145 cells and assess its virulence and immunogenicity in pigs. The A2MC2 serially passaged 90 ti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ma, Zexu, Yu, Ying, Xiao, Yueqiang, Opriessnig, Tanja, Wang, Rong, Yang, Liping, Nan, Yuchen, Samal, Siba K., Halbur, Patrick G., Zhang, Yan-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090871/
https://ncbi.nlm.nih.gov/pubmed/27805024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36312
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