GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

BACKGROUND: Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tumor cell survival and chemoresistance. The aim of our stud...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Principais autores: Cournoyer, Sonia, Addioui, Anissa, Belounis, Assila, Beaunoyer, Mona, Nyalendo, Carine, Le Gall, Roxane, Teira, Pierre, Haddad, Elie, Vassal, Gilles, Sartelet, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819521/
https://ncbi.nlm.nih.gov/pubmed/31664947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6195-y
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