Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be increased in fibrotic models; however, the role of these proteins in idiopathic pulmonary fibrosis (IPF) is not known. Here, we show that BAL cells...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Larson-Casey, Jennifer L., Vaid, Mudit, Gu, Linlin, He, Chao, Cai, Guo-Qiang, Ding, Qiang, Davis, Dana, Berryhill, Taylor F., Wilson, Landon S., Barnes, Stephen, Neighbors, Jeffrey D., Hohl, Raymond J., Zimmerman, Kurt A., Yoder, Bradley K., Longhini, Ana Leda F., Hanumanthu, Vidya Sagar, Surolia, Ranu, Antony, Veena B., Carter, A. Brent
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819144/
https://ncbi.nlm.nih.gov/pubmed/31609245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127959
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