Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be increased in fibrotic models; however, the role of these proteins in idiopathic pulmonary fibrosis (IPF) is not known. Here, we show that BAL cells...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Larson-Casey, Jennifer L., Vaid, Mudit, Gu, Linlin, He, Chao, Cai, Guo-Qiang, Ding, Qiang, Davis, Dana, Berryhill, Taylor F., Wilson, Landon S., Barnes, Stephen, Neighbors, Jeffrey D., Hohl, Raymond J., Zimmerman, Kurt A., Yoder, Bradley K., Longhini, Ana Leda F., Hanumanthu, Vidya Sagar, Surolia, Ranu, Antony, Veena B., Carter, A. Brent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819144/
https://ncbi.nlm.nih.gov/pubmed/31609245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127959
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