Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling

Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cytokines upon local inflammation, which directly contribute to vascular disease and adverse clinical outcome. Ident...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Harman, Jennifer L., Dobnikar, Lina, Chappell, Joel, Stokell, Benjamin G., Dalby, Amanda, Foote, Kirsty, Finigan, Alison, Freire-Pritchett, Paula, Taylor, Annabel L., Worssam, Matthew D., Madsen, Ralitsa R., Loche, Elena, Uryga, Anna, Bennett, Martin R., Jørgensen, Helle F.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Basic Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818986/
https://ncbi.nlm.nih.gov/pubmed/31434493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312765
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