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Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma

Preformulation studies on tofacitinib citrate, a small molecule JAK3 specific inhibitor, have not been previously reported in literature. We therefore conducted several preformulation studies on tofacitinib citrate, and its free base, to better understand factors that affect its solubility, stabilit...

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Détails bibliographiques
Publié dans:AAPS PharmSciTech
Auteurs principaux: Younis, Usir S., Vallorz, Ernest, Addison, Kenneth J., Ledford, Julie G., Myrdal, Paul B.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818719/
https://ncbi.nlm.nih.gov/pubmed/30993508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-019-1377-0
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