Genetic Variation in Surfactant Protein A2 Delays Resolution of Eosinophilia in Asthma

Surfactant protein-A (SP-A) is an important mediator of pulmonary immunity. A specific genetic variation in SP-A2, corresponding to a glutamine (Q) to lysine (K) amino acid substitution at position 223 of the lectin domain, was shown to alter the ability of SP-A to inhibit eosinophil degranulation....

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Dy, Alane Blythe C., Arif, Muhammad Z., Addison, Kenneth J., Que, Loretta G., Boitano, Scott, Kraft, Monica, Ledford, Julie G.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702058/
https://ncbi.nlm.nih.gov/pubmed/31350355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900546
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