Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism

Many clinical and preclinical studies report an increased prevalence and severity of chronic pain among females. Here, we identify a sex-hormone-controlled target and mechanism that regulates dimorphic pain responses. Prolactin (PRL), which is involved in many physiologic functions, induces female-s...

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Pubblicato in:iScience
Autori principali: Patil, Mayur, Belugin, Sergei, Mecklenburg, Jennifer, Wangzhou, Andi, Paige, Candler, Barba-Escobedo, Priscilla A., Boyd, Jacob T., Goffin, Vincent, Grattan, David, Boehm, Ulrich, Dussor, Gregory, Price, Theodore J., Akopian, Armen N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818331/
https://ncbi.nlm.nih.gov/pubmed/31627131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.039
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