Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells

Therapeutic effects of FLT3 inhibitors have been reported in acute myeloid leukemia (AML) with constitutively activating FLT3 mutations, including internal tandem duplication (ITD) and point mutation, which are found in approximately one-third of AML patients. One of the critical issues of treatment...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kawase, Tatsuya, Nakazawa, Taisuke, Eguchi, Tomohiro, Tsuzuki, Hirofumi, Ueno, Yoko, Amano, Yasushi, Suzuki, Tomoyuki, Mori, Masamichi, Yoshida, Taku
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2019
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817455/
https://ncbi.nlm.nih.gov/pubmed/31692922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27222
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