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Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers

Dual action agents containing a cysteine protease inhibitor and Rubased photosensitizer for photodynamic therapy (PDT) were designed, synthesized, and validated in 2D culture and 3D functional imaging assays of triple-negative human breast cancer (TNBC). These combination agents deliver and release...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Arora, Karan, Herroon, Mackenzie, Al-Afyouni, Malik H., Toupin, Nicholas P., Rohrabaugh, Thomas N., Loftus, Lauren M., Podgorski, Izabela, Turro, Claudia, Kodanko, Jeremy J.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816764/
https://ncbi.nlm.nih.gov/pubmed/30278123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08853
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