The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders

BACKGROUND: Patients with pre-existing neurodegenerative disease commonly experience fractures that require orthopedic surgery. Perioperative neurocognitive disorders (PND), including delirium and postoperative cognitive dysfunction, are serious complications that can result in increased 1-year mort...

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Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Miller-Rhodes, Patrick, Kong, Cuicui, Baht, Gurpreet S., Saminathan, Priyanka, Rodriguiz, Ramona M., Wetsel, William C., Gelbard, Harris A., Terrando, Niccolò
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816182/
https://ncbi.nlm.nih.gov/pubmed/31660984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1582-5
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