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The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
BACKGROUND: Amyloid-β (Aβ)-stimulated microglial inflammatory responses engage mitogen-activated protein kinase (MAPK) pathways in Alzheimer’s disease (AD). Mixed-lineage kinases (MLKs) regulate upstream MAPK signaling that include p38 MAPK and c-Jun amino-terminal kinase (JNK). However, whether MLK...
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| Publicado no: | J Neuroinflammation |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940949/ https://ncbi.nlm.nih.gov/pubmed/27401058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0646-z |
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