The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation

BACKGROUND: Amyloid-β (Aβ)-stimulated microglial inflammatory responses engage mitogen-activated protein kinase (MAPK) pathways in Alzheimer’s disease (AD). Mixed-lineage kinases (MLKs) regulate upstream MAPK signaling that include p38 MAPK and c-Jun amino-terminal kinase (JNK). However, whether MLK...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Main Authors: Dong, Weiguo, Embury, Christine M., Lu, Yaman, Whitmire, Sarah M., Dyavarshetty, Bhagyalaxmi, Gelbard, Harris A., Gendelman, Howard E., Kiyota, Tomomi
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940949/
https://ncbi.nlm.nih.gov/pubmed/27401058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0646-z
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