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URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
BACKGROUND: The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degradation. As URMC-099 promotes endolysosomal protein trafficking and reduces Aβ mic...
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| Pubblicato in: | J Neuroinflammation |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5935963/ https://ncbi.nlm.nih.gov/pubmed/29729668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1172-y |
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